Alexandra Luke was born in Montreal and trained at the Columbia Hospital, Washington to become a registered nurse. As a painter she was self-taught until 1945 when she studied with A.Y. Jackson and J.W.G. MacDonald at the Banff School of Fine Arts. She held her first solo show in Toronto at the Picture Loan Society in 1952. That same year she organized the first Canadian Abstract Travelling Exhibition. In her studio on the shore of Lake Ontario in Oshawa, the first Painters Eleven meeting took place. She went on to instruct both children and adults in art and kept herself immersed in various societies, clubs and communal activities.